For individuals 6 months to 3 years of age*:
- The maximum weekly dose of VYJUVEK gel is a volume of 0.8 milliliters (mL)
- Two syringes are used for weekly application
*For illustrative purposes only. The total surface area covered may vary. Your healthcare provider will follow the 1cm by 1cm application process based on the full Prescribing Information
It is important to continue weekly treatment of each treated wound(s) until it is fully healed. Once completely healed, other wound(s) can be treated with VYJUVEK.
Once you and your doctor have determined VYJUVEK is right for you, the next
step is to download and fill out this form with your doctor.
Hear practical guidance from a Clinical Nurse Educator on how to get your skin ready for treatment. This short video shares helpful reminders and tips to support your pre-application routine—so you can feel confident before each VYJUVEK® application.
The 24 hours before your VYJUVEK treatment is just as important as the treatment application and wound dressing. Wounds should be free of drainage, scabbing, and dead skin as much as possible, without causing additional wound damage, prior to beginning application. If you can avoid bleach or vinegar prior to application, this is recommended; if not, just ensure a proper rinse.
Diluted bleach in bathwater can be beneficial in improving the skin barrier and reducing itching.
Small amounts of bleach (at a relative dilution of 0.005% or 1/2 cup in a 40‑gallon bathtub of water /1 teaspoon in 1 gallon of water for localized soaks or compresses) do not affect how VYJUVEK works if the patient has rinsed after bathing.
Acetic acid solutions (at a relative dilution of 0.25% or 2 gallons of 5% acetic acid white vinegar in 38 gallons of bathwater for a 40‑gallon bathtub) can help to reduce Pseudomonas, a frequent colonizer of DEB wounds.
Vinegar solutions at this concentration do not affect how VYJUVEK works if the patient has rinsed after bathing.
Adults: Add 2 lbs. of salt to 40 gallons of tub water, or a half‑filled bathtub
Babies and Infants: Add 5 teaspoons of salt to each gallon of bath water
Saltwater/Epsom Salt baths do not impact how VYJUVEK works and can be taken prior to application without the need for rinsing.
Prior to VYJUVEK application, any products that contain the following should be avoided approximately 24-hours prior to application:
Anything with viricidal activity could impact VYJUVEK so reach out to your care staff with questions.
Choosing the best hydrophobic dressing can take some trial and error—and that’s okay. In this video, hear practical advice from a Clinical Nurse Educator about dressing options, tips for customizing to your needs, and how to make Vyjuvek® work effectively across different wound areas. You’re not alone in figuring it out—we’re here to help you every step of the way.
Hydrophobic means non-absorbent or water-resistant
Selecting your dressings is not a one‑size fits all decision. Finding the
right dressing for your specific needs can take time.
Through feedback and testing, we have additional hydrophobic dressing suggestions to apply over the VYJUVEK‑treated wound:
The following products have been tested and have no impact when used with Vyjuvek:
Hear practical guidance from a Clinical Nurse Educator on how to get your skin ready for treatment. This short video shares helpful reminders and tips to support your pre-application routine—so you can feel confident before each VYJUVEK® application.
The 24 hours before your VYJUVEK treatment is just as important as the treatment application and wound dressing. Wounds should be free of drainage, scabbing, and dead skin as much as possible, without causing additional wound damage, prior to beginning application. If you can avoid bleach or vinegar prior to application, this is recommended; if not, just ensure a proper rinse.
Diluted bleach in bathwater can be beneficial in improving the skin barrier and reducing itching.
Small amounts of bleach (at a relative dilution of 0.005% or 1/2 cup in a 40‑gallon bathtub of water /1 teaspoon in 1 gallon of water for localized soaks or compresses) do not affect how VYJUVEK works if the patient has rinsed after bathing.
Acetic acid solutions (at a relative dilution of 0.25% or 2 gallons of 5% acetic acid white vinegar in 38 gallons of bathwater for a 40‑gallon bathtub) can help to reduce Pseudomonas, a frequent colonizer of DEB wounds.
Vinegar solutions at this concentration do not affect how VYJUVEK works if the patient has rinsed after bathing.
Adults: Add 2 lbs. of salt to 40 gallons of tub water, or a half‑filled bathtub
Babies and Infants: Add 5 teaspoons of salt to each gallon of bath water
Saltwater/Epsom Salt baths do not impact how VYJUVEK works and can be taken prior to application without the need for rinsing.
Prior to VYJUVEK application, any products that contain the following should be avoided approximately 24-hours prior to application:
Anything with viricidal activity could impact VYJUVEK so reach out to your care staff with questions.
Choosing the best hydrophobic dressing can take some trial and error—and that’s okay. In this video, hear practical advice from a Clinical Nurse Educator about dressing options, tips for customizing to your needs, and how to make Vyjuvek® work effectively across different wound areas. You’re not alone in figuring it out—we’re here to help you every step of the way.
Hydrophobic means non-absorbent or water-resistant
Selecting your dressings is not a one‑size fits all decision. Finding the
right dressing for your specific needs can take time.
Through feedback and testing, we have additional hydrophobic dressing suggestions to apply over the VYJUVEK‑treated wound:
The following products have been tested and have no impact when used with Vyjuvek:
VYJUVEK is a topical gel used to treat wounds in patients 6 months and older with dystrophic epidermolysis bullosa (DEB).
VYJUVEK gel must be applied by a healthcare provider.
After treatment, patients and caregivers should be careful not to touch treated wounds and dressings for 24 hours. If accidentally exposed to the VYJUVEK gel, clean the affected area.
Wash hands and wear protective gloves when changing wound dressings. Disinfect bandages from the first dressing change with a virucidal agent, and dispose of the disinfected bandages in a separate sealed plastic bag in household waste. Dispose of the subsequent used dressings in a sealed plastic bag in household waste.
Patients should avoid touching or scratching wound sites or wound dressings.
The most common adverse reactions (>5%) were itching, chills, redness, rash, cough, and runny nose. These are not all the possible side effects with VYJUVEK. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or to the Sponsor at 1-844-557-9782.
VYJUVEK is a topical gel used to treat wounds in patients 6 months and older with dystrophic epidermolysis bullosa (DEB).
VYJUVEK gel must be applied by a healthcare provider.
After treatment, patients and caregivers should be careful not to touch treated wounds and dressings for 24 hours. If accidentally exposed to the VYJUVEK gel, clean the affected area.
Wash hands and wear protective gloves when changing wound dressings. Disinfect bandages from the first dressing change with a virucidal agent, and dispose of the disinfected bandages in a separate sealed plastic bag in household waste. Dispose of the subsequent used dressings in a sealed plastic bag in household waste.
Patients should avoid touching or scratching wound sites or wound dressings.
The most common adverse reactions (>5%) were itching, chills, redness, rash, cough, and runny nose. These are not all the possible side effects with VYJUVEK. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or to the Sponsor at 1-844-557-9782.
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