FOR US RESIDENTS ONLY
NOW APPROVED For the treatment of Dystrophic Epidermolysis Bullosa (DEB) in patients 6 months and older

Starting VYJUVEK

TREATMENT WITH VYJUVEK

VYJUVEK is applied weekly to your wound area(s)

  • You and your doctor can work together to develop a treatment plan for which wound/wound area(s) you treat
  • Diaper area may be an area to prioritize in young patients to prevent long-term wounding and scarring from repeated friction- and chemical-induced blistering
  • You may prioritize your hands and feet to reduce the risk of deformity/loss of function in your fingers or toes
  • Areas of higher friction, like hands, back or armpits, and larger wounds may require longer treatment compared to smaller wounds and/or wounds in low-trauma areas that may heal more quickly
  • It is important to ensure weekly treatment of each treated wound area until it is fully closed
  • Once completely closed, other wounds(s) can be treated with VYJUVEK
Phone icon
  • Tracking Your Progress
    • Take photos every week
      • It is easier to compare pictures versus daily progress with your own eyes
      • Helps document what was been treated and closed vs what has not been treated and opened
VYJUVEK™ is applied topically once weekly to promote wound healing

VYJUVEK has a maximum weekly dose dependent upon patient age

For individuals 6 months to 3 years of age*:
  • The maximum weekly dose of VYJUVEK gel is a volume of 0.8 milliliters (mL)
    • Two syringes are used for weekly application
For individuals 3 years of age and older*:
  • The maximum weekly dose of VYJUVEK gel is a volume of 1.6 milliliters (mL)
    • Four syringes are used for weekly application

*For illustrative purposes only. The total surface area covered may vary. Your healthcare provider will follow the 1cm by 1cm application process based on the full Prescribing Information

VYJUVEK should be applied in evenly spaced droplets across the wound area

  • Droplets are spaced approximately 1 cm-by-1 cm apart and look like a grid
    • Length of staple, width of finger
  • Application should begin at the top of the wound area in case of dripping
  • Once a hydrophobic dressing is applied following application, there should be enough product applied that a thin layer of VYJUVEK covers the entirety of the treated wound area.

It is important to continue weekly treatment of each treated wound(s) until it is fully healed. Once completely healed, other wound(s) can be treated with VYJUVEK.

Once you and your doctor have determined VYJUVEK is right for you, the next
step is to download and fill out this form with your doctor.

Download the Enrollment Form
IMPORTANT CONSIDERATIONS

What To Expect with Application

This section is designed to provide patients and caregivers with helpful tips on the preparation, application, and aftercare for VYJUVEK.

Before Treatment Begins: What to Know About Bathing and Wound Prep

Hear practical guidance from a Clinical Nurse Educator on how to get your skin ready for treatment. This short video shares helpful reminders and tips to support your pre-application routine—so you can feel confident before each VYJUVEK® application.

Preparation Before Application‑Bathing Considerations

The 24 hours before your VYJUVEK treatment is just as important as the treatment application and wound dressing. Wounds should be free of drainage, scabbing, and dead skin as much as possible, without causing additional wound damage, prior to beginning application. If you can avoid bleach or vinegar prior to application, this is recommended; if not, just ensure a proper rinse.

Bleach

Diluted bleach in bathwater can be beneficial in improving the skin barrier and reducing itching.

Small amounts of bleach (at a relative dilution of 0.005% or 1/2 cup in a 40‑gallon bathtub of water /1 teaspoon in 1 gallon of water for localized soaks or compresses) do not affect how VYJUVEK works if the patient has rinsed after bathing.

Vinegar

Acetic acid solutions (at a relative dilution of 0.25% or 2 gallons of 5% acetic acid white vinegar in 38 gallons of bathwater for a 40‑gallon bathtub) can help to reduce Pseudomonas, a frequent colonizer of DEB wounds.

Vinegar solutions at this concentration do not affect how VYJUVEK works if the patient has rinsed after bathing.

Salt or Epsom Salt

Adults: Add 2 lbs. of salt to 40 gallons of tub water, or a half‑filled bathtub

Babies and Infants: Add 5 teaspoons of salt to each gallon of bath water

Saltwater/Epsom Salt baths do not impact how VYJUVEK works and can be taken prior to application without the need for rinsing.

Reference: 1. Paller A, Guide S, Ayala D, Gonzalez M, Lucky A, Bagci I, Marinkovich M. Practical considerations relevant to treatment with gene therapy beremagene geperpavec-svdt for dystrophic epidermolysis bullosa. Journal of Dermatological Treatment, Volume 35, 2024. 2.VYJUVEK (beremagene geperpavec-svdt - FDA Annual Filing, Krystal Biotech 2024. ​
If you can avoid bleach or vinegar prior to application with VYJUVEK, this is recommended, if not just ensure a proper rinse.

Application Instructions

Options for bathing and preparing your skin before VYJUVEK application.

Read more

Choosing Dressings

Options for hydrophobic dressings after application with VYJUVEK.

Read more

What to Avoid 24 Hours Before VYJUVEK Application

Prior to VYJUVEK application, any products that contain the following should be avoided approximately 24-hours prior to application:

  • Bepanthen®
  • CBD
  • Calmoseptine®
  • Chlorhexidine
  • Hibiclens
  • Honey
  • Hydrogen peroxide
  • Octenisept®
  • Silver
  • Tea tree oil
  • Vashe
  • Vinegar
  • Zinc (in concentrations >12.8%)

Anything with viricidal activity could impact VYJUVEK so reach out to your care staff with questions.

If you are unable to avoid the items listed, please ensure that you rinse the wound area well, with clean water or saline prior to application. You may return to using these items after the first dressing change following VYJUVEK application.
Reference: VYJUVEK (beremagene geperpavec-svdt - FDA Annual Filing, Krystal Biotech 2024.) ​

Your healthcare provider will apply VYJUVEK
in evenly spaced droplets

  • Only the curved surface of the VYJUVEK droplet should touch the wound, with minimal pressure and avoiding contact of the skin with the syringe tip itself
  • Droplets are spaced approximately 1 cm-by-1 cm apart, and look like a grid
  • Application should begin at the top of the wound area in case of dripping

Preparation Before Application

Options for bathing and preparing your skin before VYJUVEK application.

Read more

Choosing Dressings

Options for hydrophobic dressings after application with VYJUVEK.

Read more

Finding the Right Fit: Hydrophobic Dressing Guidance

Choosing the best hydrophobic dressing can take some trial and error—and that’s okay. In this video, hear practical advice from a Clinical Nurse Educator about dressing options, tips for customizing to your needs, and how to make Vyjuvek® work effectively across different wound areas. You’re not alone in figuring it out—we’re here to help you every step of the way.

Hydrophobic Dressings: Finding What’s Right For You

Hydrophobic means non-absorbent or water-resistant

  • To make sure VYJUVEK starts working where it was applied; cover each wound or wound area treated with a non‑absorbent dressing.
    • Hydrophobic dressings (not non-absorbent)
  • After you put your non‑absorbent dressing on top of the VYJUVEK treated areas, you can put your standard dressing material (cut larger than the non‑absorbent dressing) on top to help absorb drainage and pad delicate parts of the body.
  • You can make changes to your dressings along the way; even from one wound area to another (e.g. a different dressing for your back and another type of dressing for your neck)

Selecting your dressings is not a one‑size fits all decision. Finding the
right dressing for your specific needs can take time.

References: Paller A, Guide S, Ayala D, Gonzalez M, Lucky A, Bagci I, Marinkovich M. Practical considerations relevant to treatment with gene therapy beremagene geperpavec-svdt for dystrophic epidermolysis bullosa. Journal of Dermatological Treatment, Volume 35, 2024. 2. VYJUVEK (beremagene geperpavec-svdt - FDA Annual Filing, Krystal Biotech 2024.) ​

Options for Hydrophobic Dressings

Through feedback and testing, we have additional hydrophobic dressing suggestions to apply over the VYJUVEK‑treated wound:

  • A thin layer of Vaseline® or Aquaphor® applied to the tacky side of Mepilex Lite®
  • Aquaphor®, Vaseline®, Vitamins A&D Ointment®, Coconut Oil, Shea Butter, or Burt’s Bee’s® Healing Ointment on a hydrophobic wrap (such as Glad® Wrap)
  • Atrauman® Silicone Dressings with the mesh side down and the other side retaining the plastic covering or soft plastic
  • Curity® non‑adherent dressings with the mesh side down and the other side retaining the plastic covering or soft plastic
  • Gauze saturated with Burt’s Bees Healing Ointment with dressing on top (Mepilex®)
  • Mepiform®
  • Mepitel® with the tacky side down and other side retaining the plastic covering or soft plastic
  • Silicone Scar sheets
  • Soft plastic wrap (Glad® or Saran™ Wrap)
  • Vaseline® gauze with dressing on top (Mepilex®)
  • Xeroform® petrolatum dressings with dressing on top (Mepilex®)
With the VYJUVEK application, dressings that contain Silver, Zinc, colloids, or dressings that may absorb VYJUVEK should not be used.
You can return to your standard wound care routine, including the items above, after the first dressing change following VYJUVEK application.

Additives to Hydrophobic Dressings

The following products have been tested and have no impact when used with Vyjuvek:

  • Burt’s Bee’s® healing ointment
  • Coconut Oil
  • Desitin® healing ointment (71.3% White Petrolatum)
  • Epsom Salts
  • Jojoba Oil
  • Johnson’s Baby Powder®
  • Neosporin®
  • Shea Butter
  • Sunflower Oil
  • Triple Paste® (12.8% Zinc Concentration)
Reference: VYJUVEK (beremagene geperpavec-svdt - FDA Annual Filing, Krystal Biotech 2024.) ​

Application Instructions

Options for bathing and preparing your skin before VYJUVEK application.

Read more

Preparation Before Application

Options for bathing and preparing your skin before VYJUVEK application.

Read more

Before Treatment Begins: What to Know About Bathing and Wound Prep

Hear practical guidance from a Clinical Nurse Educator on how to get your skin ready for treatment. This short video shares helpful reminders and tips to support your pre-application routine—so you can feel confident before each VYJUVEK® application.

Preparation Before Application‑Bathing Considerations

The 24 hours before your VYJUVEK treatment is just as important as the treatment application and wound dressing. Wounds should be free of drainage, scabbing, and dead skin as much as possible, without causing additional wound damage, prior to beginning application. If you can avoid bleach or vinegar prior to application, this is recommended; if not, just ensure a proper rinse.

Bleach

Diluted bleach in bathwater can be beneficial in improving the skin barrier and reducing itching.

Small amounts of bleach (at a relative dilution of 0.005% or 1/2 cup in a 40‑gallon bathtub of water /1 teaspoon in 1 gallon of water for localized soaks or compresses) do not affect how VYJUVEK works if the patient has rinsed after bathing.

Vinegar

Acetic acid solutions (at a relative dilution of 0.25% or 2 gallons of 5% acetic acid white vinegar in 38 gallons of bathwater for a 40‑gallon bathtub) can help to reduce Pseudomonas, a frequent colonizer of DEB wounds.

Vinegar solutions at this concentration do not affect how VYJUVEK works if the patient has rinsed after bathing.

Salt or Epsom Salt

Adults: Add 2 lbs. of salt to 40 gallons of tub water, or a half‑filled bathtub

Babies and Infants: Add 5 teaspoons of salt to each gallon of bath water

Saltwater/Epsom Salt baths do not impact how VYJUVEK works and can be taken prior to application without the need for rinsing.

Reference: 1. Paller A, Guide S, Ayala D, Gonzalez M, Lucky A, Bagci I, Marinkovich M. Practical considerations relevant to treatment with gene therapy beremagene geperpavec-svdt for dystrophic epidermolysis bullosa. Journal of Dermatological Treatment, Volume 35, 2024. 2.VYJUVEK (beremagene geperpavec-svdt - FDA Annual Filing, Krystal Biotech 2024. ​
If you can avoid bleach or vinegar prior to application with VYJUVEK, this is recommended, if not just ensure a proper rinse.

What to Avoid 24 Hours Before VYJUVEK Application

Prior to VYJUVEK application, any products that contain the following should be avoided approximately 24-hours prior to application:

  • Bepanthen®
  • CBD
  • Calmoseptine®
  • Chlorhexidine
  • Hibiclens
  • Honey
  • Hydrogen peroxide
  • Octenisept®
  • Silver
  • Tea tree oil
  • Vashe
  • Vinegar
  • Zinc (in concentrations >12.8%)

Anything with viricidal activity could impact VYJUVEK so reach out to your care staff with questions.

If you are unable to avoid the items listed, please ensure that you rinse the wound area well, with clean water or saline prior to application. You may return to using these items after the first dressing change following VYJUVEK application.

Your healthcare provider will apply VYJUVEK
in evenly spaced droplets

  • Only the curved surface of the VYJUVEK droplet should touch the wound, with minimal pressure and avoiding contact of the skin with the syringe tip itself
  • Droplets are spaced approximately 1 cm-by-1 cm apart, and look like a grid
  • Application should begin at the top of the wound area in case of dripping

Finding the Right Fit: Hydrophobic Dressing Guidance

Choosing the best hydrophobic dressing can take some trial and error—and that’s okay. In this video, hear practical advice from a Clinical Nurse Educator about dressing options, tips for customizing to your needs, and how to make Vyjuvek® work effectively across different wound areas. You’re not alone in figuring it out—we’re here to help you every step of the way.

Hydrophobic Dressings: Finding What’s Right For You

Hydrophobic means non-absorbent or water-resistant

  • To make sure VYJUVEK starts working where it was applied; cover each wound or wound area treated with a non‑absorbent dressing.
    • Hydrophobic dressings (not non-absorbent)
  • After you put your non‑absorbent dressing on top of the VYJUVEK treated areas, you can put your standard dressing material (cut larger than the non‑absorbent dressing) on top to help absorb drainage and pad delicate parts of the body.
  • You can make changes to your dressings along the way; even from one wound area to another (e.g. a different dressing for your back and another type of dressing for your neck)

Selecting your dressings is not a one‑size fits all decision. Finding the
right dressing for your specific needs can take time.

Options for Hydrophobic Dressings

Through feedback and testing, we have additional hydrophobic dressing suggestions to apply over the VYJUVEK‑treated wound:

  • A thin layer of Vaseline® or Aquaphor® applied to the tacky side of Mepilex Lite®
  • Aquaphor®, Vaseline®, Vitamins A&D Ointment®, Coconut Oil, Shea Butter, or Burt’s Bee’s® Healing Ointment on a hydrophobic wrap (such as Glad® Wrap)
  • Atrauman® Silicone Dressings with the mesh side down and the other side retaining the plastic covering or soft plastic
  • Curity® non‑adherent dressings with the mesh side down and the other side retaining the plastic covering or soft plastic
  • Gauze saturated with Burt’s Bees Healing Ointment with dressing on top (Mepilex®)
  • Mepiform®
  • Mepitel® with the tacky side down and other side retaining the plastic covering or soft plastic
  • Silicone Scar sheets
  • Soft plastic wrap (Glad® or Saran™ Wrap)
  • Vaseline® gauze with dressing on top (Mepilex®)
  • Xeroform® petrolatum dressings with dressing on top (Mepilex®)
With the VYJUVEK application, dressings that contain Silver, Zinc, colloids, or dressings that may absorb VYJUVEK should not be used.
You can return to your standard wound care routine, including the items above, after the first dressing change following VYJUVEK application.

Additives to Hydrophobic Dressings

The following products have been tested and have no impact when used with Vyjuvek:

  • Burt’s Bee’s® healing ointment
  • Coconut Oil
  • Desitin® healing ointment (71.3% White Petrolatum)
  • Epsom Salts
  • Jojoba Oil
  • Johnson’s Baby Powder®
  • Neosporin®
  • Shea Butter
  • Sunflower Oil
  • Triple Paste® (12.8% Zinc Concentration)
Your Patient Access Liaison is always available to answer questions;
additional support is also available through our Clinical Nurse Educators.
INDICATION AND USAGE

VYJUVEK is a topical gel used to treat wounds in patients 6 months and older with dystrophic epidermolysis bullosa (DEB).

IMPORTANT SAFETY INFORMATION

VYJUVEK gel must be applied by a healthcare provider.

After treatment, patients and caregivers should be careful not to touch treated wounds and dressings for 24 hours. If accidentally exposed to the VYJUVEK gel, clean the affected area.

Wash hands and wear protective gloves when changing wound dressings. Disinfect bandages from the first dressing change with a virucidal agent, and dispose of the disinfected bandages in a separate sealed plastic bag in household waste. Dispose of the subsequent used dressings in a sealed plastic bag in household waste.

Patients should avoid touching or scratching wound sites or wound dressings.

The most common adverse reactions (>5%) were itching, chills, redness, rash, cough, and runny nose. These are not all the possible side effects with VYJUVEK. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or to the Sponsor at 1-844-557-9782.

  • Please see Important Safety Information above and click here for full Prescribing Information.
IMPORTANT SAFETY INFORMATION
INDICATION AND USAGE

VYJUVEK is a topical gel used to treat wounds in patients 6 months and older with dystrophic epidermolysis bullosa (DEB).

IMPORTANT SAFETY INFORMATION

VYJUVEK gel must be applied by a healthcare provider.

After treatment, patients and caregivers should be careful not to touch treated wounds and dressings for 24 hours. If accidentally exposed to the VYJUVEK gel, clean the affected area.

Wash hands and wear protective gloves when changing wound dressings. Disinfect bandages from the first dressing change with a virucidal agent, and dispose of the disinfected bandages in a separate sealed plastic bag in household waste. Dispose of the subsequent used dressings in a sealed plastic bag in household waste.

Patients should avoid touching or scratching wound sites or wound dressings.

The most common adverse reactions (>5%) were itching, chills, redness, rash, cough, and runny nose. These are not all the possible side effects with VYJUVEK. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or to the Sponsor at 1-844-557-9782.

  • Please see Important Safety Information above and click here for full Prescribing Information.